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Best Nootropics for Anxiety

Robert Bergen
Medically reviewed by:
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Do you suffer from stress in social situations or from high blood pressure? Nerves can really play a number on your mind, but they’re not the same as anxiety.

General anxiety and social anxiety are just two types of anxiety disorder and doctors often prescribe pharmaceuticals to people for support. But have you heard of Nootropics for social anxiety?

They’re made from natural ingredients and work to calm the brain, relieving people from the ongoing challenges that come with stress and social anxiety.

Careful research brings us to the top anti-anxiety Nootropics for social anxiety without the harsh side effects, including our top pick to reduce anxiety, the universal Nootropic, Mind Lab Pro.

Table of Contents

Best Stacks for Anxiety and Depression

Nootropics for social anxiety and depression are a classified drug grouping that exists to help improve brain function all-around [1]. Students, who turn to them for help with studying, often refer to nootropics as “smart drugs.”

They’re touted as a suitable alternative to many of the addictive prescription drugs on the market and contain little-to-no adverse side effects, thanks to the safe ingredients.

This includes things such as B Vitamins and other substances that easily cross the blood brain barrier, providing the brain with nutrients. Stress and social anxiety symptoms can lessen as such.

Companies craft (stack) careful combinations of natural remedies, minerals, and more. Nootropic stacks consist of different ingredients, depending on the particular issues the Nootropic tackles, be it social anxiety and depression.

The top 6 Nootropics for social anxiety symptoms and stress that may help many people are as follows:

1. Mind Lab Pro Anxiety Nootropic

Mind Lab Pro is a universal Nootropic that contains a highly-potent combination of safe and effective ingredients. The plant-based capsules feature 11 different Nootropics to boost cognitive function in the brain, and help alleviate stress, anxiety and depression.

It’s the most powerful Nootropic, best for social anxiety and offsetting side effects of generalized anxiety. The ingredients included in Mind Lab Pro are:

  • Citicoline
  • Phosphatidylserine
  • Bacopa Monnieri
  • Organic Lion's Mane Mushroom
  • Maritime Pine Bark Extract
  • L-Tyrosine
  • L-Theanine
  • Rhodiola Rosea
  • B vitamins (B6, B9, B12)

2. Performance Lab Nootropics

This company features a Nootropics stack for social anxiety consisting of four main ingredients to support concentration and focus and increase blood flow to the brain. 

It’s GMP-certified meaning Performance Lab meets strict production standards and the Nootropic pills are vegan-friendly, too. The ingredients are as follows:
  • Citicoline
  • Phosphatidylserine
  • L-Tyrosine
  • Maritime Pine Bark Extract

3. NooCube Nootropic for Anxiety

Do you suffer from high-stress levels? NooCube contains amino acids and vitamins for enhancing mental performance. 

This Nootropic increases mental energy, which can otherwise take a hit from social anxiety. Multitasking and concentration may also increase to avoid the onset of panic attacks. There’s no caffeine or GMOs included in this supplement.

Ingredients include:
  • Alpha GPC
  • Huperzine A
  • Cat’s Claw
  • Bacopa Monnieri 
  • Oat Straw
  • L-Theanine and L-Tyrosine

4. BrainPill Nootropic

BrainPill brings us another Nootropic to help calm the mind and prevent the stress and depression associated with social anxiety. 

The company built it to improve mental processing and combat brain fatigue, as well. This may help people with anxiety who suffer from slow learning and exhaustion. The 13 Nootropics in BrainPill include:

  • Citicoline
  • Tyrosine
  • Phosphatidylserine
  • B Vitamins including B12, B6, B5, B9
  • L-Theanine
  • Bacopa Monnieri
  • Huperzine A
  • Vinpocetine
  • Ginkgo Biloba
  • DHA Complex

5. Qualia Mind

It’s a high-performance, anti-stress and anti-anxiety Nootropic that contains the highest level of ingredients on our list. This includes amino acids and antioxidants. It may help increase mental clarity in the brain and prevent panic attacks, which many people with stress and anxiety often suffer from. You could see an uptick in creativity and energy, as well.

It can also lift your mood with its support of Dopamine production, one of the essential neurotransmitters [2].

Qualia Mind features an astounding 28 ingredients:
  • Vitamin C
  • Vitamin D3
  • Thiamine
  • Niacin
  • B Vitamins (B6, B12)
  • Pantothenic Acid
  • Acetyl-L-Carnitine
  • Artichoke Leaf Extract
  • Bacopa Monnieri
  • Rhodiola Rosea Root Extract
  • DL-Phenylalanine
  • Uridine-5
  • L-Tyrosine and L-Theanine
  • Taurine
  • Alpha GPC
  • CognizinⓇ
  • Organic CoffeeberryⓇ
  • Velvet Bean Seed Extract
  • Phosphatidylserine
  • Theobromine
  • DHA
  • Celastrus Paniculatus Seed Extract
  • Ginkgo Biloba
  • Coleus Forskohlii Root Extract
  • Huperzine A
  • Pyrroloquinoline Quinone

6. Alpha Brain Nootropic

Alpha Brain brings us an example of Nootropics for social anxiety and depression and stress that may help improve memory, focus and brain processing time. 

Suffering panic attacks could be a thing of the past. Research shows that it supports mental clarity through a combination of carefully-selected natural ingredients, all beneficial for the mind [3].

The ingredients in Alpha Brain include:
  • Vitamin B6
  • L-Tyrosine and L-Theanine
  • Oat Straw Extract
  • Phosphatidylserine
  • Cat’s Claw Extract
  • Alpha GPC
  • Bacopa Monnieri Extract
  • Huperzia Serrata Extract
  • L-Leucine
  • Vinpocetine
  • Pterostilbene

The Most Effective Nootropic for Anxiety — How Popular Ingredients Affect Anxiety Levels

Different anxiety conditions demand various treatments and these supplements aren’t intended to diagnose one from the other. Instead, they all work to improve brain performance and reduce social anxiety at large. They don’t come with any awful side effects, either.

Whether people suffer from regular panic attacks or have a hard time in social situations, there are specific ingredients that may help. All of these have the ability to cross the blood brain barrier which is the pathway for nutrients that need to reach the brain.


Mind Lab Pro, one of the best Nootropics, contains the majority of what’s listed below. The following natural substances work to combat panic attacks, anxiety and more:

 L Tyrosine

L Tyrosine is an amino acid proven to mitigate the stress that accompanies social anxiety and could further reduce panic attacks as a result [4]. It does this by lowering cortisol levels (the stress hormone that heightens blood pressure) and supporting the production of dopamine in the brain, which is one of the vital neurotransmitters.

This further indicates that this amino acid may help in protecting the mind against mood swings and difficulty with concentration, common effects of anxiety on the brain.

 Lion’s Mane Mushroom

Lion’s Mane Mushroom is an edible fungus that serves as a natural remedy. It can help in treating disorders such as Dementia, while relieving minor symptoms of depression and anxiety. 

It’s considered to be an anti-inflammatory, which is one of the causes of many conditions, while it also helps in the regeneration of cells [5]

 Ashwagandha

This relaxant is a natural substance commonly cited in Ayurveda medicine as a solution for battling stress, panic attacks and challenges with relaxation. It does this by lowering cortisol levels and increasing brain function. 

As a result, Ashwagandha can heighten energy levels, offsetting one of the many consequences of social anxiety [6].

 Ginkgo Biloba

Ginkgo Biloba is a potent antioxidant that’s used for fighting cognitive decline [7]. It also helps with memory recall, focus, and lowering blood pressure. This indicates it can also support people who suffer from panic attacks, allowing them a presence of mind. 

You’ll often find Ginkgo Biloba combined with green tea.

 DHA

This omega-3 fatty acid links to better heart health, lowering the heart rate and reducing inflammation in the body [8]. It increases blood flow and may help with conditions such as ADHD.

Studies show that omega-3s, in general, help in preventing the negative effects of anxiety and depression disorders by increasing relaxation and lowering blood pressure [9]. This might help with further preventing panic attacks.

 Rhodiola Rosea

Rhodiola Rosea is a flower that many people have used over the years to fight anxiety, panic attacks, depression and fatigue. It’s also used to treat minor symptoms of bipolar disorder and ADHD. 

Research shows that Rhodiola Rosea supports the immune system and optimized physiological functions, while lowering stress levels [10].

 Bacopa Monnieri

This perennial herb exists in many Nootropics for social anxiety, which signals its success in boosting brain performance. It’s a staple plant of Ayurveda medicine and known as an antioxidant, with anti inflammatory effects.

Studies point to Bacopa Monnieri as an option for lowering cortisol levels, one of the difficulties of social anxiety and depression and the probability of panic attacks [11]

 Citicoline

Citicoline is the top ingredient in Mind Lab Pro and many other anti-anxiety supplements on the market. It’s classified as a “neuroprotector” and supports the production of phosphatidylcholine, which is a brain chemical that aids in memory recall [12]

The latter is one of the common side effects of anxiety and depression, leading to high stress levels.

 Maritime Pine Bark

People use this natural extract for treating stress levels that accompany social situations, anxiety disorders, and panic attacks. It’s considered as an antioxidant, as well, supporting cognitive function among older people [13].

Maritime Pine Bark may also help in improving blood flow and stimulating the immune system, which can take a hit for people with high stress.

 Phosphatidylserine

Phosphatidylserine is an important phospholipid which is a fatty tissue in the brain. This substance helps the cells communicate and manages cortisol, as well, which is also known as the “stress hormone.” People with social anxiety and who suffer from panic attacks often have high cortisol levels.

Research indicates that this fatty tissue can also help in battling depression, yet another common effect of anxiety [14].

The Most Powerful Nootropic Stack According to Research

According to research, Mind Lab Pro is the top pick for the most powerful Nootropic, containing B vitamins and more. It features 11 crucial ingredients, stacked to create a potent combination for boosting brain power and lessening social anxiety symptoms.

The majority of these, including Citicoline, Bacopa Monnieri, and Rhodiola Rosea come with substantive research pointing to their efficacy in fighting anxiety, depression, and panic attacks. This makes it a suitable choice for athletes, those older than 55 years, and students that face difficulties accompanying anxiety disorders.

The Nootropic contains no allergens or animal products either, so it’s safe for those with sensitivities and vegan dietary restrictions. 

Nootropics that Increase Dopamine — Stacking for Anxiety

Dopamine is one of the essential neurotransmitters that your body uses for sending signals between cells. It plays a role in pleasure perception, thinking, and planning [15]

People that suffer from anxiety and panic attacks understand the frustration that comes with lacking mental clarity and an increase in Dopamine can help with this factor.

The top two Nootropics for social anxiety that increase Dopamine include Mind Lab Pro and Qualia Mind. Both include L Tyrosine which supports the production of this important neurotransmitter.

What’s the Best Supplement for Anxiety?

There are loads of other supplements, setting aside Nootropics, on the market aimed at squelching the effects of anxiety and depression and easing the brain.

Phenibut and Anxiety — The Unfiltered Truth

Phenibut is an anti-anxiety medication that was first prescribed in Russia in the 1960s. It’s a synthetic form of GABA, one of the main neurotransmitters in the brain [16].

GABA does produce a calm and relaxed feeling in one’s body, though that’s the only main ingredient in Phenibut.

This makes the supplement dangerous because withdrawal effects are often severe, leading people to heighten their dose in response.

Does Noopept Help With Anxiety?

This “cognitive enhancer” stimulates the brain for optimal performance. It may help in staving off cognitive decline.

However, it’s recommended that those with social anxiety avoid Noopept as it can produce a similar effect as caffeine does, which can actually increase anxiety and panic attacks in difficult situations.

How L Theanine Calms People Down

Commonly found in some mushrooms and green tea, L Theanine is an amino acid that increases relaxation without making you sleepy. This enables your mind to calm down enough to focus and go about your daily routine with a pleasant, energized demeanor.

L Theanine is a popular ingredient in Nootropics for social anxiety for this reason, including Mind Lab Pro.

GABA and Anxiety — What You Should Know

As mentioned above, GABA is another one of the important neurotransmitters that produces a state of relaxation. Though when ingested on its own or in high quantities, it may have a poor effect on those that suffer anxiety and panic attacks.

It can also lead to drowsiness and poor brain activity when abused, which you should avoid. Otherwise it could cause an even greater increase in anxiety and panic attacks.

L Theanine and GABA — Which Is Better? (Per the Evidence)

Per the evidence in this review, the best supplements for anxiety contain L Theanine or similar ingredients, not GABA.

Stacking for Anxiety — Factors to Consider

Combining the best Nootropics, or “stacking,” is how companies create most of these products on the list. How the ingredients function and support one another is a crucial part of how successful a certain Nootropic is for people.

Synergy

Synergy is the main goal of stacking Nootropics for anxiety. In a way, it means that the combined value of certain ingredients is greater than the sum of its separate parts.

Mind Lab Pro is the best example of this. Let’s look at two of the primary ingredients, Citicoline and Phosphatidylserine.

Citicoline helps in the production of phosphatidylserine, which lowers cortisol levels, a goal for those with anxiety and anyone who struggles with panic attacks. 

Multiplication

Multiplication on the other hand, works to target the same “bioeffect” through different pathways, offering greater results.

If we use our best pick, Mind Lab Pro, as another example here, it contains both Bacopa Monnieri and Rhodiola Rosea. These ingredients support the immune system in their own ways.

Lowered immunity is often one of the effects in those with anxiety, due to the stress output on the body and brain. This indicates that an increase in immunity may, in turn, help manage stress and anxiety levels, helping keep panic attacks at bay.

Complementation

Complementation is exactly as it sounds. Do the ingredients within a certain Nootropic support one another or cause negative effects?

There aren’t any Nootropics for anxiety on the list that contain ingredients with adverse effects, given that all the substances are, by and large, natural and safe. It’s yet another reason we recommend Mind Lab Pro as our top choice.

Final Word on Best Nootropics for Anxiety

The best Nootropics for social anxiety feature a well-researched combination of natural substances to help ease the effects of this difficult condition in a safe way. They do this by crossing the blood brain barrier to help the brain receive crucial nutrients.

Are you one of these people who suffer from anxiety or stress in social situations? Seeking out Nootropics for anxiety could be an alternative solution to the dangerous side effects of pharmaceuticals on the market. Remedies such as L Theanine and B Vitamins might surprise you.

Mind Lab Pro is one of our top picks to reduce anxiety and lower the effects of this condition such as stress. This universal Nootropic features the best ingredients for fighting anxiety, panic attacks and depression, promoting a slew of other benefits including better immunity and relaxation with better energy levels.

Remember, the best Nootropics for anxiety won’t contain caffeine or other harmful ingredients. This way, people can enjoy the other anti stress and anxiety benefits without all of that jitteriness that comes from one of the other drugs.

References

  1. Suliman, Noor Azuin, et al. “Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic.” Evidence-Based Complementary and Alternative Medicine : ECAM, Hindawi Publishing Corporation, 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5021479/.
  2. “Safety and Efficacy Study of Qualia Mind on Cognition in a Healthy Population – Full Text View.” Full Text View – ClinicalTrials.gov, clinicaltrials.gov/ct2/show/NCT04389723.
  3. Solomon, Todd M, et al. “A Randomized, Double-Blind, Placebo Controlled, Parallel Group, Efficacy Study of Alpha BRAIN® Administered Orally.” Journal of the International Society of Sports Nutrition, BioMed Central, 21 Sept. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4595564/.
  4. Young, Simon N. “L-Tyrosine to Alleviate the Effects of Stress?” Journal of Psychiatry & Neuroscience : JPN, U.S. National Library of Medicine, May 2007, www.ncbi.nlm.nih.gov/pmc/articles/PMC1863555/.
  5. Lai PL;Naidu M;Sabaratnam V;Wong KH;David RP;Kuppusamy UR;Abdullah N;Malek SN; “Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium Erinaceus (Higher Basidiomycetes) from Malaysia.” International Journal of Medicinal Mushrooms, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/24266378/.
  6. Pratte, Morgan A, et al. “An Alternative Treatment for Anxiety: a Systematic Review of Human Trial Results Reported for the Ayurvedic Herb Ashwagandha (Withania Somnifera).” Journal of Alternative and Complementary Medicine (New York, N.Y.), Mary Ann Liebert, Inc., Dec. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4270108/.
  7. Zhang, Hong-Feng, et al. “An Overview of Systematic Reviews of Ginkgo Biloba Extracts for Mild Cognitive Impairment and Dementia.” Frontiers in Aging Neuroscience, Frontiers Media S.A., 6 Dec. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5138224/.
  8. Swanson, Danielle, et al. “Omega-3 Fatty Acids EPA and DHA: Health Benefits throughout Life.” Advances in Nutrition (Bethesda, Md.), Oxford University Press, Jan. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3262608/.
  9. Jacka, Felice N., et al. “Dietary Intake of Fish and PUFA, and Clinical Depressive and Anxiety Disorders in Women: British Journal of Nutrition.” Cambridge Core, Cambridge University Press, 10 Oct. 2012, www.cambridge.org/core/journals/british-journal-of-nutrition/article/dietary-intake-of-fish-and-pufa-and-clinical-depressive-and-anxiety-disorders-in-women/1DCCC8ADE55414BC1DDB7B54C2DFA689.
  10. Li, Yonghong, et al. “Rhodiola Rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention.” Current Pharmacology Reports, U.S. National Library of Medicine, Dec. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC6208354/.
  11. Benson S;Downey LA;Stough C;Wetherell M;Zangara A;Scholey A; “An Acute, Double-Blind, Placebo-Controlled Cross-over Study of 320 Mg and 640 Mg Doses of Bacopa Monnieri (CDRI 08) on Multitasking Stress Reactivity and Mood.” Phytotherapy Research : PTR, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/23788517/.
  12. Iulia, Chitu, et al. “Citicoline – a Neuroprotector with Proven Effects on Glaucomatous Disease.” Romanian Journal of Ophthalmology, Romanian Society of Ophthalmology, 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5710031/.
  13. Simpson, Tamara, et al. “Assessing the Efficacy and Mechanisms of Pycnogenol® on Cognitive Aging From In Vitro Animal and Human Studies.” Frontiers in Pharmacology, Frontiers Media S.A., 3 July 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6619435/.
  14. Komori, Teruhisa. “The Effects of Phosphatidylserine and Omega-3 Fatty Acid-Containing Supplement on Late Life Depression.” Mental Illness, PAGEPress Publications, Pavia, Italy, 1 Apr. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4508628/.
  15. Berke, Joshua D. “What Does Dopamine Mean?” Nature Neuroscience, U.S. National Library of Medicine, June 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6358212/.
  16. “The Efficacy of Irvingia Gabonensis Supplementation in the Management of Overweight and Obesity: A Systematic Review of Randomized Controlled Trials.” Taylor & Francis, www.tandfonline.com/doi/full/10.3109/19390211.2012.760508.

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